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Glutamat inducerad skada
The Na +-glutamate transporters on neurons and astrocytes can reverse their glutamate transport and start secreting glutamate at a concentration capable of inducing excitotoxicity. This results in a buildup of glutamate and further damaging activation of glutamate receptors.
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Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity that ultimately leads to the loss of neuronal function and cell death.
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ICT treatment significantly reduced glutamate-induced neuronal damage but showed no cytotoxicity in the absence of glutamate. These results suggest that ICT is a potential neuroprotective agent that is capable of ameliorating excitatory toxicity induced by glutamate.
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We found that glutamate triggers a sustained increase of extracellular ATP levels, which contributes for glutamate-induced hippocampal neuronal death through the activation of P2Y1R.
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This review provides a summary on the toxicity of monosodium glutamate and the protective effects of natural products against monosodium glutamate -induced toxicity. Key Words: Food industry, Herbal medicine, Monosodium glutamate, Neurotoxicity, Phytochemical.
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Glutamat är den huvudsakliga excitatoriska neurotransmittorn i centrala nervsystemet (CNS).
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Således var unga möss fortfarande känsliga för dopamin-inducerad skada, emedan de vid månaders ålder uppvisade mycket små skador efter dopamin injektion.
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